Clinical Study on NAD + and references
Based on the available information from various sources, including clinical trials and systematic reviews, the evidence for targeting NAD therapeutically has shown promise in addressing age-related conditions and potential benefits for human health. Here are some key findings from the available sources: 1. NAD+ Precursors and Therapeutic Potential: Clinical evidence and preclinical studies have highlighted the potential therapeutic utility of NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), in addressing age-related conditions, metabolic dysfunction, and cognitive health. These precursors have been studied extensively in animal and cell models, showing promising results in ameliorating metabolic dysfunction, muscle decline, and potentially preventing cognitive decline across various disease contexts
2. Clinical Trials and Human Studies: Several clinical trials and human studies have been conducted to assess the efficacy and safety of NAD+ precursors in elevating NAD+ levels, improving cardiovascular parameters, and potentially addressing aging-associated pathologies. These studies have demonstrated that NAD+ precursors, such as nicotinamide riboside, are well-tolerated and may have the potential to improve physiological functions with aging in humans
3. Age-Dependent Reduction of Cellular NAD+: Emerging evidence from preclinical and human studies indicates an age-dependent reduction of cellular NAD+, possibly due to reduced synthesis and increased consumption. This has led to the exploration of NAD+ augmentation strategies as a potential approach for improving cellular functions and addressing age-related pathologies
In conclusion, the clinical evidence for targeting NAD therapeutically, particularly through the use of NAD+ precursors, has shown promise in addressing age-related conditions, metabolic dysfunction, and potential benefits for human health. Further research and properly controlled clinical trials are needed to fully understand the therapeutic potential and long-term effects of NAD+ precursors in various disease contexts.
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